Look on the Internet "ready psd mockups download" , download , look , what are there sizes . You can look for ready-made site layouts with the grid to see how everything is done. This is a topic, do different...
I think it is necessary to make several layouts of one landing. One layout for wide screens, one for tablets and one for phones.
For a wide for example to arrange the blocks in 4 columns, tablet, 2 columns of phone numbers in 1 column
here's an example here